Force-generation and dynamic instability of microtubule bundles
نویسندگان
چکیده
منابع مشابه
Generation of microtubule stability subclasses by microtubule- associated proteins: implications for the microtubule "dynamic instability" model
We have developed a method to distinguish microtubule associated protein (MAP)-containing regions from MAP-free regions within a microtubule, or within microtubule sub-populations. In this method, we measure the MAP-dependent stabilization of microtubule regions to dilution-induced disassembly of the polymer. The appropriate microtubule regions are identified by assembly in the presence of [3H]...
متن کاملMicrotubule dynamic instability
What are microtubules? One of three types of protein polymer that make up the cellular cytoskeleton, an elaborate array of filaments that are used to establish cell shape, facilitate cell motility, organize organelles and assist with cell division. Microtubules are stiff tubes, about 25 nm in diameter. During interphase, they serve as tracks on which organelles and the nucleus are positioned by...
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Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time and are thus attuned to the cell cycle and differe...
متن کاملForce Generation by Molecular-Motor-Powered Microtubule Bundles; Implications for Neuronal Polarization and Growth
The heavily cross-linked microtubule (MT) bundles found in neuronal processes play a central role in the initiation, growth and maturation of axons and dendrites; however, a quantitative understanding of their mechanical function is still lacking. We here developed computer simulations to investigate the dynamics of force generation in 1D bundles of MTs that are cross-linked and powered by mole...
متن کاملKinetics and mechanism of microtubule length changes by dynamic instability.
Microtubules at steady state were found to undergo dramatic changes in length, with only very little change in number concentration and mean length. This result is accounted for by a mechanism in which microtubules are capped at ends by tubulin-GTP subunits; loss of the tubulin-GTP cap at one end results in disassembly of all the tubulin-GDP subunits, so that the medial edge of the distal tubul...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424
DOI: 10.1073/pnas.0710311105